When you have a donor who upgrades their giving, especially those that move dramatically to the 5-figure level, do not just put them through your normal thank you receipting process. Get out of your office and go see them. Get face to face with that donor and thank them. Ask them to explain the decision making process and their trusted advisers that helped them with the decision. Before you know that single gift will blossom into five or six major gifts, but only if you take the time to meet and cultivate real friendships.